Spread of the arthrogryposis multiplex (AM) and developmental duplication (DD) genetic defects among the Russian populations of aberdeen angus cattle

In this paper it have been described the genetic defects of arthrogriposis multiplex (AM) and developmental duplication (DD). In 2018 in L.K. Ernst Federal Science Center, the mutations caused AM and DD were studied, and on the base of obtained knowledges, it have been developed PCR test systems for the detection of the mutant alleles. By means the developed test systems we carried out the investigation of 2585 heads of cattle including 2244 bulls, 270 cows and 71 repair heifers. All animals belonged to thirty-eight populations breeding in different subjects of Russian Federation (Central and North-West Federal districts). All investigated livestock (n=2585) was analyzed on Developmental duplication genetic defect. The animals of twelve populations (n=1206) have been also investigated on genetic defect of arthrogriposis multiplex. The analysis has shown the presence the animals-carriers of arthrogriposis multiplex in three of twelve investigated populations in frequencies of 0.7-1.0%, and animals-carriers of genetic defect developmental duplication - in all populations in frequencies of 0.7-38.2%. The obtained results is the reflection of the chaotic in relation of genetic defects animals selection and confirm the necessity of development as the diagnostic measures as a strategy of the genetic anomalies control in Aberdeen Angus cattle on territory of Russian Federation.

AM, DD, cattle, Aberdeen Angus breed, genetic defect, Developmental duplication, Arthrogriposis multiplex, AM, DD

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