The correlation between the concentration of enzymes of the POL-AO system in serum and rat brain tissue
https://doi.org/10.31043/2410-2733-2020-2-16-20
Abstract
Violations of normal metabolism lead to increased generation of active oxygen forms in cells, the excess of which creates conditions for the formation of oxidative stress. For a variety of reasons, the brain is most sensitive to this condition: brain tissue is adapted to high oxygen consumption, they contain more oxidized substrate and less active antioxidant protection system. Therefore, oxidative stress can be attributed to the most significant mechanisms of neurocyte and glia damage, as it triggers pathological reactions that irreversibly damage cells and lead to the launch of genetically programmed neuronal death - apoptosis. The article presents the study of interrelationships between the concentration distribution of enzymes of POL-AO system in blood serum and brain tissue of white pedigree rats. Using Spirman, Gamma and Kendel Tau correlation coefficients it was revealed that studying the activity distribution of enzymes of POL-AO system in blood serum and rat brain tissues reliable direct correlation links of weak force between SOD activity in blood serum and rat brain tissues were revealed (Gamma = 0.12 at p ≤ 0.039282); Kendall Tau = 0.11 at p ≤ 0.039282) and the concentration of diene conjugates in rat serum and rat brain tissue (Gamma = 0.16 at p ≤ 0.007167; Kendall Tau = 0.15 at p ≤ 0.007167).
About the Authors
P. Boriskin
LLC TestGen
Russian Federation
Russian Federation
PhD (Med. Sci.); research associate
432072, Ulyanovsk, 44th passage Engineering, 9
O. Gulenko
Medical University «Reaviz»
Russian Federation
PhD (Biol. Sci.)443001, Samara, st. Chapaevskaya, 227
Russian Federation
PhD (Biol. Sci.)443001, Samara, st. Chapaevskaya, 227
A. Devyatkin
LLC TestGen
Russian Federation
Russian Federation
PhD (Med. Sci.); research associate
432072, Ulyanovsk, 44th passage Engineering, 9
R. Karimova
FSBEI of HE «Kazan State Academy of Veterinary Medicine named after N. E. Bauman»
Russian Federation
Russian Federation
Dr. Habil. (Biol. Sci.), professor
420029, Kazan, ul. Siberian tract, 35
V. Leonov
Medical University «Reaviz»
Russian Federation
Russian Federation
laboratory assistant
443001, Samara, st. Chapaevskaya, 227
O. Pavlova
LLC TestGen
Russian Federation
Russian Federation
Dr. Habil. (Biol. Sci.), research associate
432072, Ulyanovsk, 44th passage Engineering, 9
A. Toropovsky
LLC TestGen
Russian Federation
Russian Federation
PhD (Med. Sci.); general director
432072, Ulyanovsk, 44th passage Engineering, 9
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Review
For citations:
Boriskin P., Gulenko O., Devyatkin A., Karimova R., Leonov V., Pavlova O., Toropovsky A. The correlation between the concentration of enzymes of the POL-AO system in serum and rat brain tissue. Genetics and breeding of animals. 2020;(2):16-20. (In Russ.) https://doi.org/10.31043/2410-2733-2020-2-16-20
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