Use of antioxidant «Tiophan-M» for correction of disorders of bone tissue structure caused by long-term reception of glucocorticoids
https://doi.org/10.31043/2410-2733-2020-2-21-26
Abstract
This study explores the possibility of using the sulfur-containing antioxidant Thiofan-M for the correction of structural and functional disorders of bone tissue induced by prolonged use of glucocorticoid drugs. The development of oxidative stress in animals was induced by daily administration of a prednisolone synthetic glucocorticoid Prednisolone (Nycomed Austria GmbH, Austria) per os daily at a dose of 50 mg / kg. Morphometric indicators of modeling and remodeling of bone tissue and structural and functional features of bone tissue of vertebral bodies were studied using a complex of optical-structural analysis based on AxioImager.M2 with AxioVision Z2 M2 software (Carl Zeiss, Germany). Inductively coupled argon plasma atomic emission spectroscopy (Optima 2100 DV spectrometer, Perkin Elmer, USA) determined the Ca and P contents in the studied samples. It was established that long-term use of glucocorticoids leads to significant negative changes in the histoarchitectonics of the bone tissue of vertebral bodies and disruption exchange of the most important osteotropic macronutrients. The use of the polyfunctional sulfur-containing antioxidant «Tiofan-M» render a pronounced osteoprotective effect, reduces the level of bone resorption and can be considered as a promising means of free radical protection of cells and bone matrix with long-term use of glucocorticoids.
About the Authors
S. Lukanina
FSBEI of HE «Novosibirsk State Pedagogical University»
Russian Federation
Russian Federation
PhD (Biol. Sci.)
630126, Novosibirsk Region, Novosibirsk, Vilyuiskaya St., 28
A. Sakharov
FSBEI of HE «Novosibirsk State Pedagogical University»
Russian Federation
Russian Federation
Dr. Habil. (Biol. Sci.)
630126, Novosibirsk Region, Novosibirsk, Vilyuiskaya St., 28
О. Prosenko
FSBEI of HE «Novosibirsk State Pedagogical University»
Russian Federation
Russian Federation
PhD (Chem. Sci.)
630126, Novosibirsk Region, Novosibirsk, Vilyuiskaya St., 28
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Review
For citations:
Lukanina S., Sakharov A., Prosenko О. Use of antioxidant «Tiophan-M» for correction of disorders of bone tissue structure caused by long-term reception of glucocorticoids. Genetics and breeding of animals. 2020;(2):21-26. (In Russ.) https://doi.org/10.31043/2410-2733-2020-2-21-26
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