Study of ischemic depolarization in focal cerebral ischemia in rats
https://doi.org/10.31043/2410-2733-2022-2-70-75
Abstract
Purpose: to study ischemic depolarization in focal cerebral ischemia in rats.
Materials and methods. We conducted simulations of focal cerebral ischemia in 30 rats. The animals were divided into three groups: 1) normothermia (n = 10), 2) hypothermia (n = 10), 3) hyperthermia (n = 10). We identified a statistically significant correlation between the animal's body temperature and the number of episodes of depolarization. (r = 0,87, p<0,001). The average number of DC potential deviations in animals with hyperthermia was statistically significantly higher than in animals with normothermia. (p<0,05).
Results. Tissue damage as a result of focal cerebral ischemia correlates with body temperature fluctuations. A decrease in body temperature in focal cerebral ischemia leads to a decrease in the size of the ischemia zone, and as a result of a cerebral infarction, and vice versa, a slight increase in body temperature leads to an increase in the area of cerebral infarction.
Conclusion. On tissue, temperature fluctuations have physiological and biochemical effects, a statistically significant correlation between episodes of depolarization in cerebral ischemia and the percentage of brain damage after ischemia are not always in a cause-and-effect relationship.
About the Authors
N. Vechkanova
N. P. Ogarev Mordovia State University
Russian Federation
Russian Federation
Vechkanova N. – PhD (Biol. Sci.)
430005, Russia, Republic of Mordovia, Saransk, Bolshevistskaya st., 68
N. Melnikova
N. P. Ogarev Mordovia State University
Russian Federation
Russian Federation
Melnikova N. – PhD (Biol. Sci.)
430005, Russia, Republic of Mordovia, Saransk, Bolshevistskaya st., 68
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Review
For citations:
Vechkanova N., Melnikova N. Study of ischemic depolarization in focal cerebral ischemia in rats. Genetics and breeding of animals. 2022;(2):70-75. (In Russ.) https://doi.org/10.31043/2410-2733-2022-2-70-75
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