The effect of zeolites on oxidative stress and the immune system
https://doi.org/10.31043/2410-2733-2022-2-125-131
Abstract
Purpose: Analysis of literary sources about the influence of zeolites on oxidative stress and the immune system of a living organism.
Over the past two decades, many substances of natural or synthetic origin have been studied as potential alternatives to antibiotics - growth stimulants, and some of them, especially immunomodulators and nutricatics, have shown the ability to stimulate the function of the immune system and improve the general state of health. At the same time, it was shown that they are harmless to animals and the environment. The promising results,were obtained with natural clay minerals - zeolites, most famous as zootechnical and biomedical food.,The review presents a brief description of some links in the oxidative stress mechanism. The effect of the,additives of zeolites on a decrease in the total number of lipids and LDL (low density lipoproteins) is indicated,,which can also be indirectly associated with its general antioxidant effect.,The exact mechanisms of the action of zeolites on the systemic restoration of homeostasis and the increase,in antioxidant ability have not yet been fully studied. There is also evidence that Zeolites have antibacterial and,antiviral effects. These effects are most likely associated both with the general detoxification effects occurring,in the intestines, and with immunomodulating influences or even with the release of physiologically significant,cations from the zeolite frame during the Ion exchange process. Similar indirect effects of zeolite on antioxidant,mechanisms in the body were also observed with various pathologies and models of diseases.
About the Authors
M. Akimova
Ulyanovsk State Agrarian University named after P.A. Stolypin
Russian Federation
Russian Federation
Akimova M. – postgraduate student
432000, Russia, Ulyanovsk, Ulyanovsk Region, new crown, 1
S. Dezhatkina
Ulyanovsk State Agrarian University named after P.A. Stolypin
Russian Federation
Russian Federation
Dezhatkina S. - Dr. Habil (Biol. Sci.), Professor
432000, Russia, Ulyanovsk, Ulyanovsk Region, new crown, 1
References
1. Hayyan M. Superoxide ion: generation and chemical implications / M. Hayyan, M. A. Hashim, I. M. Alnashef // Chemical reviews. – 2016. – V. 116. – №. 5. – Р. 3029–3085. doi: 10.1021/acs.chemrev.5b00407
2. Covarrubias L. Function of reactive oxygen species during animal development: passive or active? / L. Covarrubias, D. Hernández-García et al. // Developmental biology. – 2018. – V. 320. – №. 1. – Р. 1–11. doi: 10.1016/j.ydbio.2018.04.041
3. Waris G. Reactive oxygen species: role in the development of cancer and various chronic conditions / G. Waris, H. Ahsan //Journal of carcinogenesis. – 2006. – V. 5. – Р. 14. doi: 10.1186/1477-3163-5-1
4. Inoue M. Mitochondrial generation of reactive oxygen species and its role in aerobic life / M. Inoue, E. F. Sato et al. // Curr Med Chem. – 2013. – V. 10. – Р. 2495–2505. doi: 10.2174/0929867033456477
5. Valko M. Role of oxygen radicals in DNA damage and cancer incidence / M. Valko, M. Izakovic et al. // Molecular and cellular biochemistry. – 2019. – V. 266. – №. 1. – Р. 37–56.
6. Rahman K. Studies on free radicals, antioxidants, and co-factors / K. Rahman // Clinical interventions in aging. – 2017. – V. 2. – №. 2. – Р. 219.
7. Aseervatham G. S. B. Environmental factors and unhealthy lifestyle influence oxidative stress in humans – an overview / G. S. B. Aseervatham, T. Sivasudha et al. // Environmental Science and Pollution Research. – 2013. – V. 20. – №. 7. – Р. 4356–4369.
8. Chen X. Reactive oxygen species regulate T cell immune response in the tumor microenvironment / X. Chen, M. Song et al. // Oxidative Medicine and Cellular Longevity. – 2016. – V. 2016. doi: 10.1155/2016/1580967
9. Miranda-Díaz A. G. Oxidative stress in diabetic nephropathy with early chronic kidney disease / A. G. Miranda-Díaz, L. Pazarín-Villaseñor et al. // Journal of diabetes research. – 2016. – V. 2016. doi: 10.1155/2016/7047238
10. Patel M. Targeting oxidative stress in central nervous system disorders / M. Patel // Trends in pharmacological sciences. – 2016. – V. 37. – №. 9. – Р. 768–778 doi: 10.1016/j.tips.2016.06.007
11. Srikanthan K. The role of Na/K-ATPase signaling in oxidative stress related to obesity and cardiovascular disease / K. Srikanthan, J. I. Shapiro, K. Sodhi // Molecules. – 2016. – V. 21. – №. 9. – Р. 1172. doi: 10.3390/molecules21091172
12. Ding C. Peroxiredoxin 1–an antioxidant enzyme in cancer / C. Ding, X. Fan, G. Wu // Journal of cellular and molecular medicine. – 2017. – V. 21. – №. 1. – Р. 193–202. doi: 10.1111/jcmm.12955
13. Rahman K. Studies on free radicals, antioxidants, and co-factors / K. Rahman // Clinical interventions in aging. – 2007. – V. 2. – №. 2. – Р. 219.
14. Cutovic M. Clinoptilolite for treatment of dyslipidemia: preliminary efficacy study. / M. Cutovic, M. Lazovic et al. // J. Altern Complement. Med. – 2016. – V. 23. – Р. 738–744. doi: 10.1089/acm.2016.0414
15. Lamprecht M. Effects of zeolite supplementation on parameters of intestinal barrier integrity, inflammation, redoxbiology and performance in aerobically trained subjects / M. Lamprecht, S. Bogner et al. // J. Int. Soc. Sports Nutr. – 2015. – V. 12. – Р. 40–51. doi: 10.1186/s12970-015-0101-z
16. Saribeyoglu K. Effects of clinoptilolite treatment on oxidative stress after partial hepatectomy in rats / K. Saribeyoglu // Asian J. Surg. – 2011. – V. 34. – Р. 153–157. doi: 10.1016/j.asjsur.2011.11.007
17. Wu Q. J. Effects of clinoptilolite and modified clinoptilolite on the growth performance, intestinal microflora, and gut parameters of broilers / Q. J. Wu, L. C. Wang et al. // Poultry Science. – 2013. – V. 92. – №. 3. – Р. 684–692. doi: 10.3382/ps.2012-02308
18. Zarkovic N. Anticancer and antioxidative effects of micronized zeolite clinoptilolite / N. Zarkovic, K. Zarkovic et al. //Anticancer research. – 2003. – V. 23. – №. 2B. – Р. 1589-1595.
19. Madhusudhan N. Fluoride-induced neuronal oxidative stress and its amelioration by antioxidants in developing rats / N. Madhusudhan, P. M. Basha, S. Begum, F. Ahmed // Fluoride. – 2009. – V. 42. – №. 3. – Р. 179.
20. Jahanbakhsh S. Impact of medicated feed along with clay mineral supplementation on Escherichia coli resistance to antimicrobial agents in pigs after weaning in field conditions / S. Jahanbakhsh, K. P. Kabore et al. // Research in veterinary science. – 2015. – V. 102. – Р. 72–79. doi: 10.1016/j.rvsc.2015.07.014
21. Akhmetova V.V. Indicators of the tissue metabolism of the organism of animals against the background of a citrateceolite additive / V.V. Akhmetov, A. Z. Mukhitov, L.P. Pulcherovskaya // Bulletin of the Ulyanovsk State Agricultural Academy. - 2018. - No. 4 (44). - P.118-122.
22. Grigoryev V. S. Dynamics of resistance factors in pigs of different genotypes in postnatal ontogenesis / V. S. Grigoryev, I. N. Khakimov, S. V. Dzhakin // Scientists of the Kazan State Academy of Veterinary Medicine named after N.E. Bauman. - 2019. - T. 240. - No. 4. - P. 65–70.23. Shlenkina T. M. The use of sedimentary zeolite for fattening pig / T. M. Shlenkina, N. A. Lyubin et al. // Russian Journal of Agricultural and Socio-Economic Sciences. – 2019. – № 12 (96). – P. 287–292.
23. Lyubin N. A. Application of sedimentary zeolite in dairy cattle breeding / N. A. Lyubin, S. V. Dezhatkina et al. // Russian Journal of Agricultural and Socio-Economic Sciences. – 2020. – № 1 (97). – C. 113–119.
24. Rodríguez-Fuentes G. Enterex: Anti-diarrheic drug based on purified natural clinoptilolite / G. Rodríguez-Fuentes, M. A. Barrios et al. // Zeolites. – 1997. – V. 19. – №. 5-6. – Р. 441–448. doi: 10.1016/S0144-2449(97)00087-0
25. Potgieter W. Potentiated clinoptilolite: artificially enhanced aluminosilicate reduces symptoms associated with endoscopically negative gastroesophageal reflux disease and nonsteroidal anti-inflammatory drug induced gastritis / W. Potgieter, C. S. Samuels, J. R. Snyman // Clinical and experimental gastroenterology. – 2014. – V. 7. – Р. 215. doi: 10.2147/CEG.S51222
26. Grce M. Antiviral properties of clinoptilolite / M. Grce, K. Pavelić // Microporous and Mesoporous Materials. – 2005. – V. 79. – №. 1–3. – Р. 165–169. doi: 10.1016/j.micromeso.2004.10.039
27. Ivkovic S. Dietary supplementation with the tribomechanically activated zeolite clinoptilolite in immunodeficiency: effects on the immune system / S. Ivkovic, U. Deutsch et al. //Advances in therapy. – 2004. – V. 21. – №. 2. – Р. 135–147. doi: 10.1007/BF02850340
28. Kraljević Pavelić S. Critical review on zeolite clinoptilolite safety and medical applications in vivo / Kraljević Pavelić S., Simović Medica J. et al. // Frontiers in Pharmacology. – 2018. – V. 9. – Р. 1350.
Review
For citations:
Akimova M., Dezhatkina S. The effect of zeolites on oxidative stress and the immune system. Genetics and breeding of animals. 2022;(2):125-131. (In Russ.) https://doi.org/10.31043/2410-2733-2022-2-125-131
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