Study of fatty acid metabolism in rat heart and brain tissues against the background of acute hemic hypoxia and antihypoxant loadings

The study of metabolic disorders caused by hypoxia is an important area of medicine and biochemistry, since such conditions can be key factors in the development of serious clinical diseases. One of the main consequences of hypoxia is the development of hypoenergetic states, in which there is increased lipid hydrolysis. At the same time, active synthesis of fatty acids is also observed, which leads to their increased concentration in blood and tissues. The multiplicity of pathophysiological changes in the organism under hypoxia requires the search for effective antihypoxants. Promising antihypoxants are extracts of black currant and medicinal raspberry.

The aim of the study was to investigate the peculiarities of fatty acid metabolism in rat heart and brain tissues against the background of acute histotoxic hypoxia and antihypoxant loading.

Materials and methods. The studies were performed on 180 white mongrel rats. The animals were divided equally into 6 groups. According to group affiliation, animals received intragastrically extracts of black currant, medicinal raspberry, a mixture of these extracts in the ratio of 1:1 and cytochrome C, which was administered intramuscularly, for 15 days. A model of histotoxic hypoxia was used. Absolute and relative concentration of fatty acids (FA) was determined in rat brain and heart tissues.

Results. An increase in the concentration of fatty acids in all studied tissues was found in acute histotoxic hypoxia, which is an indicator of disorders of lipid and carbohydrate metabolism, which may contribute to the failure of adaptation mechanisms. Additional loading of rats with antihypoxants on the background of acute hypoxia contributed to a decrease in the concentration of fatty acids in tissues, which indicates that the studied preparations have a high lipidoprotective and antioxidant effect, and the highest efficiency is demonstrated by a mixture of extracts of medicinal raspberry and black currant in a ratio of 1:1.

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