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The influence of phytobiotics on the body of animals (mammals and birds) (review)

https://doi.org/10.31043/2410-2733-2025-4-22-35

Abstract

Objective: to summarize and analyze the effects of phytobiotics on the physiological state of animals (mammals and poultry).
Materials and Methods. To achieve this objective, a scientific literature search was conducted using elibrary.ru, PubMed, Web of Science, and Scopus, with an emphasis on studies from the past five years focused primarily on growth-promoting properties.
Results. This review article provides a summary of the effects of phytobiotics on the physiological state of animals (mammals and poultry). The intensification of livestock farming is increasingly leading to the need for synthetic drugs produced by pharmaceutical companies. Antibiotics, including feed antibiotics, have a significant impact on the growth-promoting properties of the body. Their irrational use leads to microbial resistance to the active ingredients of drugs, meaning their subsequent use will no longer have a therapeutic effect. All these factors are leading scientists to search for alternative treatments that are equally effective as these medications. Phytobiotics could be such substances. Phytobiotics have a positive effect on the gastrointestinal tract and help stabilize the balance between normal flora, pathogenic, and opportunistic microorganisms. Equally important is research into phytobiotics as antioxidants. Further research should focus on optimizing dosages, studying synergism between various phytogenic compounds, and developing effective commercial formulations for widespread adoption in livestock and poultry farming.

About the Authors

L. A. Nikanova
Federal Research Center for Animal Husbandry named after Academy Member L. K. Ernst
Russian Federation

Nikanova Lyudmila Anatolyevna - Dr Habil. (Biol. Sci.), leading scientific researcher of Department of Physiology and Biochemistry of Farm Animals

Dubrovitsy 60, Podolsk Municipal District, Moscow Region, 142132



V. I. Maksimov
Federal State Budgetary Educational Institution of Higher Education «Moscow State Academy of Veterinary Medicine and Biotechnology – MVA named after K. I. Skryabin»
Russian Federation

Maksimov Vladimir Ilyich - Dr Habil. (Biol. Sci.), professor, professor of the Department of Physiology, Pharmacology and Toxicology named after A. N. Golikov and I. E. Mozgov

Academician Skryabin street 23, Moscow, 109472



K. A. Berezova
Federal Research Center for Animal Husbandry named after Academy Member L. K. Ernst
Russian Federation

Berezova Ksenia Alekseevna - postgraduate student

Dubrovitsy 60, Podolsk Municipal District, Moscow Region, 142132



References

1. Hashemi S. R. Herbal plants and their derivatives as growth and health promoters in animal nutrition / S. R. Hashemi, H. Davoodi // Veterinary Research Communications. — 2011. — Vol. 35. — № 3. — P. 169–180. doi: 10.1007/s11259-010-9458-2.

2. Kim S. W. Understanding intestinal health in nursery pigs and the relevant nutritional strategies / S. W. Kim, M. E. Duarte // Animal bioscience. — 2021. — Vol. 34. — № 3. — P. 338–344. doi: 10.5713/ab.21.0010.

3. Farr M. M. Sulfamerazine therapy in experimental cecal coccidiosis of chickens / M. M. Farr, E. E. Wehr // The Journal of Parasitology. — 1945. —Vol. 31. — № 6. — P. 353–358. doi: 10.2307/3273032.

4. Moore P. R. Use of sulfasuxidine, streptothricin, and streptomycin in nutritional studies with the chick / P. R. Moore et al. // Journal of Biological Chemistry. — 1946. — Vol. 165. — № 2. — P. 437–441. doi: 10.1016/S0021-9258(17)41154-9.

5. Whitehill A. R. Stimulatory effect of aureomycin on the growth of chicks / A. R. Whitehill, J. J. Oleson, B. L. Hutchings // Experimental Biology and Medicine. — 1950. — Vol. 74. — № 1. — P. 11–13. doi: 10.3181/00379727-74-17793.

6. Carpenter L. E. The effect of antibiotics and vitamin B12 on the growth of swine / L. E. Carpenter // Archives of Biochemistry and Biophysics. – 1951. – Vol. 32. – № 2. – P. 187–191. doi: 10.1016/0003-9861(51)90252-4.

7. Cunha T. J. A comparison of aureomycin, streptomycin, penicillin and an aureomycin-B12 feed supplement for the pig / T. J. Cunha, G. B. Meadows, H. M. Edwards et al. // Archives of Biochemistry. – 1951. – Vol. 30. – № 2. – P. 269–271.

8. Luecke R. W. The growth promoting effects of various antibiotics on pigs / R. W. Luecke, F. Thorp, H. W. Newland et al. // Journal of Animal Science. – 1951. – Vol. 10. – № 2. – P. 538–542. doi: 10.2527/jas1951.102538x.

9. Becker D. E. Supplementary protein and the response of the pig to antibiotics / D. E. Becker, S. W. Terrill, R. A. Noetzold // Journal of Animal Science. – 1955. – Vol. 14. – № 2. – P. 492–498. doi: 10.2527/jas1955.142492x.

10. Cromwell G. L. Why and how antibiotics are used in swine production / G. L. Cromwell // Animal Biotechnology. – 2002. – Vol. 13. – № 1. – P. 7–27. doi: 10.1081/ABIO-120005767.

11. Kim S. W. Nonruminant nutrition symposium on natural phytobiotics for health of young animals and poultry: mechanisms and application / S. W. Kim, M. Z. Fan, T. J. Applegate // Journal of Animal Science. – 2008. – Vol. 86. – № 14, suppl. – P. 138–139. doi: 10.2527/jas.2007-0769.

12. Casewell M. The European ban on growth-promoting antibiotics and emerging consequences for human and animal health / M. Casewell et al. // Journal of Antimicrobial Chemotherapy. – 2003. – Vol. 52. – P. 159–161. doi: 10.1093/jac/dkg313.

13. Sneeringer S. The U.S. and EU animal pharmaceutical industries in the age of antibiotic resistance / S. Sneeringer, M. Bowman, M. Clancy. – Washington, DC, USA : USDA, 2019. – 50 p.

14. Schoenmakers K. How China is getting its farmers to kick their antibiotics habit / K. Schoenmakers // Nature. – 2020. – Vol. 586. – P. S60–S62. doi: 10.1038/d41586-020-02889-y.

15. Liu R. H. Potential synergy of phytochemicals in cancer prevention: mechanism of action / R. H. Liu // The Journal of Nutrition. – 2004. – Vol. 134. – № 12. – P. 3479—3485. doi: 10.1093/jn/134.12.3479S.

16. Kikusato M. Phytobiotics to improve health and production of broiler chickens: functions beyond the antioxidant activity / M. Kikusato // Animal Bioscience. – 2021. – Vol. 34. – № 3. – P. 345–353. doi: 10.5713/ab.20.0842.

17. Timofeev N. P. Phytobiotics in World Practice: Plant Species and Active Ingredients, Efficiency and Limitations, Prospects (Review) / N. P. Timofeev // Agrarian Science of the Euro-North-East. — 2021. — Vol. 22. — № 6. — P. 804—825.

18. Bagno O. A. Phytobiotics in Farm Animal Feeding / O. A. Bagno, O. N. Prokhorov, et al. // Agricultural Biology. — 2018. — Vol. 53. — № 4. — P. 687—697. doi: 10.15389/agrobiology.2018.4.687rus.

19. Podobed L. I. Phytobiotics in animal feeding / L. I. Podobed // Animal Husbandry of Russia. — 2019. — № S2. — P. 34—35.

20. Popova G. M. On the possibilities of using phytobiotic additives in the diets of farm animals / G. M. Popova, B. S. Nurzhanov, G. K. Duskaev // Animal Husbandry and Forage Production. — 2023. — Vol. 106. — № 2. — P. 127—135. doi: 10.33284/2658-3135-106-2-127.

21. Sizentsov A. N. Improving the nutritional characteristics of fish using phytobiotics and probiotics in feeding (review) / A. N. Sizentsov, E. P. Miroshnikova, et al. // Agrarian Bulletin of the Urals. — 2023. — № 3. — P. 52—63. doi: 10.32417/1997-4868-2023-232-03-52-63.

22. Cherkashina N. V. Analysis of the current state of the problem of using antibiotics as a feed additive / N. V. Cherkashina et al. // Agrarian Bulletin of the Urals. — 2011. —№ 3 (82). — P. 39—42.

23. Timofeev N. P. Phytobiotics in world practice: plant species and active substances, efficiency and limitations, perspectives (review) / N. P. Timofeev // Agricultural Science Euro-North-East. – 2021. – Vol. 22. – P. 804—825. doi: 10.30766/2072-9081.2021.22.6.804-825.

24. Nikanova L. A. The role of biologically active substances – phytoextracts of larch bark in pig productivity / L. A. Nikanova, V. I. Maksimov, K. A. Berezova // Bulletin of OrelSAU. – Orel. — 2024. — № 1 (106). – P. 47—50. doi: 10.17238/issn2587-666X.2024.1.47.

25. Windisch W. Use of phytogenic products as feed additives for swine and poultry / W. Windisch, K. Schedle, C. Plitzner et al. // Journal of Animal Science. – 2008. – Vol. 86. – P. 140–148.

26. Mohammadi Gheisar M. Phytobiotics in poultry and swine nutrition – a review / M. Mohammadi Gheisar, I.H. Kim // Italian Journal of Animal Science. – 2017. – Vol. 17. – № 1. – P. 92–99. doi: 10.1080/1828051X.2017.1350120.

27. Kiczorowska B. The natural feed additives as immunostimulants in monogastric animal nutrition – a review / B. Kiczorowska, W. Samolińska, A. R. M. Al-Yasiry et al. // Annals of Animal Science. – 2017. – Vol. 17. – № 3. – P. 605–625. doi: 10.1515/aoas-2016-0076.

28. Huyghebaert G. An update on alternatives to antimicrobial growth promoters for broilers / G. Huyghebaert, R. Ducatelle, F. Van Immerseel // Veterinary Journal. – 2011. – Vol. 187. – № 2. – P. 182–188.

29. Bakkali F. Biological effects of essential oils—a review / F. Bakkali, S. Averbeck, D. Averbeck et al. // Food and Chemical Toxicology. – 2008. – Vol. 46. – № 2. – P. 446–475.

30. Burt S. Essential oils: their antibacterial properties and potential applications in foods—a review / S. Burt // International Journal of Food Microbiology. – 2004. – Vol. 94. – № 3. – P. 223–253.

31. Pandey S. Cutting-edge knowledge on the roles of phytobiotics and their proposed modes of action in swine / S. Pandey, E.S. Kim, J.H. Cho et al. // Frontiers in Veterinary Science. – 2023. – Vol. 10. – Article 1265689. doi: 10.3389/fvets.2023.1265689.

32. Krauze M. Phytobiotics, a natural growth promoter for poultry / M. Krauze // Advanced studies in the 21st century animal nutrition / ed. by L. Babinszky, J. Oliveira, E. Mauro Santos. – London : IntechOpen Limited, 2021.

33. Lillehoj H. Phytochemicals as antibiotic alternatives to promote growth and enhance host health / H. Lillehoj, Y. Liu, S. Calsamiglia et al. // Veterinary Research. – 2018. – Vol. 49. – № 1. – Article 76. doi: 10.1186/s13567-018-0562-6.

34. Manzanilla E. Effect of plant extracts and formic acid on the intestinal equilibrium of early-weaned pigs / E. Manzanilla, J. Perez, M. Martin et al. // Journal of Animal Science. – 2004. – Vol. 82. – № 11. – P. 3210–3218. doi: 10.2527/2004.82113210x.

35. Jang I. Effect of a commercial essential oil on growth performance, digestive enzyme activity and intestinal microflora population in broiler chickens / I. Jang, Y. Ko, S. Kang et al. // Animal Feed Science and Technology. – 2007. – Vol. 134. – № 3-4. – P. 304–315. doi: 10.1016/j.anifeedsci.2006.06.009.

36. Diaz-Sanchez S. Botanical alternatives to antibiotics for use in organic poultry production / S. Diaz-Sanchez et al. // Poultry Science. – 2015. – Vol. 94. – № 6. – P. 1419–1430. doi: 10.3382/ps/pev014.

37. Costa L. Herbal extracts and organic acids as natural feed additives in pig diets / L. Costa, F. Luciano et al. // South African Journal of Animal Science. – 2013. – Vol. 43. – № 2. – P. 181–193.

38. Kim J. D. Effects of feed additive as an alternative for antibiotics on growth performance and feed cost in growing-finishing pigs / J. D. Kim, J. A. Sherwin, K. S. Shim // Korean Journal of Organic Agriculture. – 2010. – Vol. 18. – № 2. – P. 233—244. doi: 10.3390/ani13020200.

39. Li P. Effects of Adding Essential Oil to the Diet of Weaned Pigs on Performance, Nutrient Utilization, Immune Response and Intestinal Health / P. Li, X. Piao, Y. Ru et al. // Asian-Australasian Journal of Animal Sciences. – 2012. – Vol. 25. – № 11. – P. 1617—1626. doi: 10.5713/ajas.2012.12292.

40. Mohammadi Gheisar M. Inclusion of phytogenic blends in different nutrient density diets of meat-type ducks / M. Mohammadi Gheisar, Y. M. Im, H. H. Lee et al. // Poultry Science. – 2015. – Vol. 94. – № 12. – P. 2952—2958. doi: 10.3382/ps/pev301.

41. Kumar M. Application of herbal feed additives in animal nutrition – a review / M. Kumar, V. Kumar, D. Roy et al. // International Journal of Livestock Research. – 2014. – Vol. 4. – № 1. – P. 1—8.

42. Iranparast F. The effect of oral consumption of guggul (Commiphora mukul) resin on performance and humoral immunity response of broilers / F. Iranparast, S. Parsaei et al. // International Journal of Advanced Biological and Biomedical Research. – 2014. – Vol. 2. – № 3. – P. 802—810.

43. Bakht J. Antimicrobial potentials of fresh Allium cepa against gram positive and gram negative bacteria and fungi / J. Bakht et al. // Pakistan Journal of Botany. – 2013. – Vol. 45. – № S1. – P. 1—6.

44. Al-Mariri A. In vitro antibacterial activity of several plant extracts and oils against some gram-negative bacteria / A. Al-Mariri, M. Safi // Iranian Journal of Medical Sciences. – 2014. – Vol. 39. – № 1. – P. 36—43.

45. Trukhachev V. I. Use of phytobiotics in feeding monogastric animals (review) / V. I. Trukhachev, M. I. Selivanova, A. Yu. Zagarin // Bulletin of the Timiryazev Agricultural Academy. — 2023. — № 1 (4). — P. 126—143. doi: 10.26897/0021-342X-2023-4-126-143.

46. Nikanova L. A. Effect of larch bark extract on the metabolic status and productivity of piglets / L. A. Nikanova, O. A. Artemyeva // Problems of veterinary sanitation, hygiene and ecology. — 2024. — № 2 (50). — P. 285—291.

47. Liu H. N. Effects of dietary supplementation of quercetin on performance, egg quality, cecal microflora populations, and antioxidant status in laying hens / H. N. Liu, Y. Liu, L. L. Hu et al. // Poultry Science. – 2014. – Vol. 93. – № 2. – P. 347—353. doi: 10.3382/ps.2013-03225.

48. Manafi M. Comparison study of a natural non-antibiotic growth promoter and a commercial probiotic on growth performance, immune response and biochemical parameters of broiler chicks / M. Manafi // Journal of Poultry Science. – 2015. – Vol. 52. – № 4. – P. 274—281. doi: 10.2141/jpsa.0150027.

49. Soyadi Y. Phytobiotics in Poultry Industry as Growth Promoters, Antimicrobials and Immunomodulators – A Review / Y. Soyadi, W. Abd El-Ghany // Journal of World's Poultry Research. – 2020. – Vol. 10. – № 4. – P. 571—579. doi: 10.36380/jwpr.2020.65.

50. Agarwal C. In vitro antioxidant and antibacterial activities with polyphenolic profiling of wild cherry, the European larch and sweet chestnut tree bark / C. Agarwal, T. Hofmann, M. Vršanská et al. // European Food Research and Technology. – 2021. – Vol. 247. – № 9. – P. 2355–2370. doi: 10.1007/s00217-021-03796-w.

51. Chrubasik S. Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles / S. Chrubasik, M. H. Pittler, B. D. Roufogalis // Phytomedicine. – 2005. – Vol. 12. – № 9. – P. 684-701. doi: 10.1016/j.phymed.2004.07.009.

52. Platel K. Stimulatory influence of select spices on bile secretion in rats / K. Platel, K. Srinivasan // Nutrition Research. – 2000. – Vol. 20. – № 10. – P. 1447—1456. doi: 10.1016/S0271-5317(00)00233-5.

53. Rao R. R. In vitro influence of spices and spice-active principles on digestive enzymes of rat pancreas and small intestine / R. R. Rao et al. // Nahrung. – 2003. – Vol. 47. – № 6. – P. 408–412.

54. Kroismayr A. Effects of essential oils or Avilamycin on gut microbiology and blood parameters of weaned piglets / A. Kroismayr, J. Sehm, M. Pfaffl et al. // Czech Journal of Animal Science. – 2008. – Vol. 53. – № 9. – P. 377—387.

55. Kyriakis S. C. Control of post weaning diarrhea syndrome of piglets by in-feed application of Origanum essential oils / S. C. Kyriakis, K. Sarris et al. // Proceedings of the 15th IPVS Congress. – Birmingham, UK, 5-9 July, 1998. – Vol. 3. – P. 218.

56. Zadorozhnaya M. V. Use of betulin in poultry farms to enhance post-vaccination antiviral immunity in birds. / M. V. Zadorozhnaya, S. B. Lysko et al. // Bulletin of Omsk State Agrarian University. – 2012. – № 4 (8). – P. 97–91.

57. Lysko S. B. Immunomodulatory efficacy of pine-based herbal preparations for vaccination of broiler chickens against Newcastle disease. / S. B. Lysko, M. V. Zadorozhnaya et al. // Poultry farming. – Sergiev Posad. – 2023. – № 5. – P. 70—74.

58. Zaki M. M. Effect of certain phytobiotics on the immune response of Newcastle disease vaccinated broiler chickens / M. M. Zaki et al. // Asian Journal of Poultry Science. – 2016. – Vol. 10. – № 3—4. – P. 134—140. doi: 10.3923/ajpsaj.2016.134.140.

59. Ahmed S. T. Effects of resveratrol and essential oils on growth performance immunity, digestibility and fecal microbial shedding in challenged piglets / S. T. Ahmed et al. // Asian-Australasian Journal of Animal Sciences. – 2013. – Vol. 26. – № 5. – P. 683—690. doi: 10.5713/ajas.2012.12683.

60. Frankic T. Use of herbs and spices and their extracts in animal nutrition / T. Frankic, M. Voljg, J. Salobir et al. // Acta Agriculturae Slovenica. – 2009. – Vol. 92. – № 2. – P. 95–102.

61. Daka D. Antibacterial effect of garlic (Allium sativum) on Staphyloccus aureus: An in vitro study / D. Daka // African Journal of Biotechnology. – 2013. – Vol. 10. – № 4. – P. 666–669.

62. Gautam R. K. Drug resistance and antifungal activity of garlic and neem extracts on Candida spp. isolates from HIV-infected patients / R. K. Gautam, A. P. Garg // International Journal of Advanced Pharmaceutical Research. – 2013. – Vol. 4. – № 4. – P. 1426–1433.

63. Pourali M. Effects of garlic powder on productive performance and immune response of broiler chickens challenged with Newcastle Disease virus / M. Pourali, S. A. Mirghelenj, H. Kermanshahi // Global Veterinaria. – 2010. – Vol. 4. – № 6. – P. 616–621.

64. Toghyani M. Evaluation of cinnamon and garlic as antibiotic growth promoter substitutions on performance, immune responses, serum biochemical and haematological parameters in broiler chicks / M. Toghyani, M. Toghyani et al. // Livestock Science. – 2011. – Vol. 138. – № 1-3. – P. 167–173.

65. Mahmood S. Comparative efficacy of Nigella sativa and Allium sativum as growth promoters in broilers / S. Mahmood, M. Mushtaq-Ul-Hassan, M. Alam et al. // International Journal of Agriculture and Biology. – 2009. – Vol. 11. – № 6. – P. 775–778.

66. Elagib H. A. A. Effect of dietary garlic (Allium sativum) supplementation as feed additive on broiler performance and blood profile / H. A. A. Elagib, W. I. A. El-Amin et al. // Journal of Animal Science Advances. – 2013. – Vol. 3. – № 2. – P. 58–64.

67. Hanieh H. Modulatory effects of two levels of dietary Alliums on immune response and certain immunological variables, following immunization, in White Leghorn chickens / H. Hanieh, K. Narabara, M. Piao et al. // Animal Science Journal. – 2010. – Vol. 81. – № 6. – P. 673–680.

68. Grela E. R. Effect of inulin and garlic supplementation in pig diets / E. R. Grela, K. Pietrzak, S. Sobolewska et al. // Annals of Animal Science. – 2013. – Vol. 13. – № 1. – P. 63–71.

69. Czech A. The effect of a herbal extract used in pig fattening on the animals' performance and blood components / A. Czech, E. Kowalczuk, E. Grela // Annales UMCS, Zootechnica. – 2009. – Vol. 27. – № 3. – P. 25–32.

70. Lee S. D. The effect of ginger extracts on the antioxidant capacity and IgG concentrations in the colostrum and plasma of neo-born piglets and sows / S. D. Lee, J. H. Kim et al. // Livestock Science. – 2013. – Vol. 154. – № 1—3. – P. 117–122.

71. Nabi F. Editorial: Treatment of animal diseases with veterinary phytotherapy / F. Nabi, D. Shi, Q. Wu et al. // Frontiers in Veterinary Science. – 2023. – Vol. 10. – Article 1171987. doi: 10.3389/fvets.2023.1171987.

72. Nabi F. An updated review on efficiency of penthorum chinense pursh in traditional uses, toxicology, and clinical trials / F. Nabi, J. Ahmed, W. Tao et al. // BioMed Research International. – 2023. – Vol. 2023. – Article 4254051. doi: 10.1155/2023/4254051.

73. Nabi F. Effect of in ovo trace element supplementation on immune-related cells of the small intestine of post-hatched broiler chicken / F. Nabi, M. A. Arain, S. A. Fazlani et al. // Biological Trace Element Research. – 2022. – Vol. 201. – № 5. – P. 1—10. doi: 10.1007/s12011-022-03492-0.

74. Wu S. Challenges of fluoride pollution in environment: mechanisms and pathological significance of toxicity–a review / S. Wu, Y. Wang et al. // Environmental Pollution. – 2022. – Vol. 304. – Article 119241. doi: 10.1016/j.envpol.2022.119241.

75. Botsoglou N. A. The effects of dietary oregano essential oil and α-tocopheryl acetate on lipid oxidation in raw and cooked turkey during refrigerated storage / N. A. Botsoglou, S. H. Grigoropoulou et al. // Meat Science. – 2003. – Vol. 65. – № 3. – P. 1193–1200. doi: 10.1016/S0309-1740(03)00029-9.

76. Cuppett S. L. Antioxidant activity of the Labiatae / S. L. Cuppett, C. A. Hall // Advances in Food and Nutrition Research. – 1998. – Vol. 42. – P. 245–271. doi: 10.1016/s1043-4526(08)60097-2.

77. Janz J. A. M. Preliminary investigation of the effects of low-level dietary inclusion of fragrant essential oils and oleoresins on pig performance and pork quality / J. A. M. Janz, P. C. H. Morel, B. H. P. Wilkinson et al. // Meat Science. – 2007. – Vol. 75. – № 2. – P. 350–355. doi: 10.1016/j.meatsci.2006.06.027.

78. Saeed M. In ovo delivery of various biological supplements, vaccines and drugs in poultry: current knowledge / M. Saeed, M. A. Arain, D. Babazadeh et al. // Journal of the Science of Food and Agriculture. – 2019. – Vol. 99. – № 8. – P. 3727–3739.

79. Wang Q. Monomeric compounds from traditional Chinese medicine: new hopes for drug discovery in pulmonary fibrosis / Q. Wang, W. Li, H. Hu et al. // Biomedicine & Pharmacotherapy. – 2023. – Vol. 159. – Article 114226. doi: 10.1016/j.biopha.2023.114226.

80. Saeed M. A comprehensive review on the health benefits and nutritional significance of fucoidan polysaccharide derived from brown seaweeds in human, animals and aquatic organisms / M. Saeed et al. // Aquaculture Nutrition. – 2021. – Vol. 27. – № 3. – P. 633–654. doi: 10.1111/anu.13233.

81. Kamatou G.P.P. A review of the application and pharmacological properties of α-bisabolol and α-bisabolol-rich oils / G. P. P. Kamatou, A. M. Viljoen // Journal of the American Oil Chemists' Society. – 2010. – Vol. 87. – № 1. – P. 1–7. doi: 10.1007/s11746-009-1483-3.

82. Kim T. V. Hepatoprotective activity of betulonic acid and its derivatives in experimental polychemotherapy / T. V. Kim, O. R. Grek et al. // Bulletin of Medical Academic Science. — 2010. — № 1. — P. 28—29.

83. Adepoju F. O. Pharmacological Potential of Betulin as a Multitarget Compound / F. O. Adepoju et al. // Biomolecules. – 2023. – Vol. 13. – № 7. – Article 1105. doi: 10.3390/biom13071105.


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Nikanova L.A., Maksimov V.I., Berezova K.A. The influence of phytobiotics on the body of animals (mammals and birds) (review). Genetics and breeding of animals. 2025;(4):22-35. (In Russ.) https://doi.org/10.31043/2410-2733-2025-4-22-35

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