The relationship of the concentration distribution of diene conjugates in the blood serum and tissues of white outbred rats
https://doi.org/10.31043/2410-2733-2020-1-50-54
Abstract
It is known that lipids are the building material of cell membranes, play an important role in the vital functions of cells, and this is a peculiar form of deposition of metabolic fuel reserves. In the last decade, thanks to numerous studies, it has been established that lipids are an integral part of the general metabolism and are actively involved in the processes of adaptation and regulation of many functions in the body. Disorders of lipid metabolism are the trigger in the pathogenesis of numerous diseases. The basis of many metabolic processes in the body is redox reactions. Uncompensated formation of reactive oxygen species or oxidative stress leads to a violation of the physiological activity of cell membranes, which leads to a violation of the integrity of the cell and triggers a cascade of degenerative processes, resulting in exponentially accelerated aging. The state of lipid peroxidation is estimated by the content of intermediate products - diene conjugates (DCs), since they reflect the early stages of oxidation. The aim of our study was to study the relationship between the distribution of concentration of diene conjugates in the blood serum and tissues of white outbred rats. To achieve this goal, the following tasks had to be solved: to determine the concentration of diene conjugates in the blood serum and tissues of the liver, brain, heart, as well as in the skeletal muscle tissues of rats; to reveal the relationship between the distribution of DC concentration in blood serum and rat tissues. The article presents the results of a nonparametric correlation analysis to assess the relationship between the distribution of concentration of diene conjugates in blood serum and tissues of outbred rats.
About the Authors
O. Pavlova
LLC «TestGen»
Russian Federation
Russian Federation
Dr. Habil. (Biol. Sci.), research associate
432072, Ulyanovsk, 44th passage Engineering, house 9
O. Gulenko
Medical University «Reaviz»
Russian Federation
Russian Federation
PhD (Biol. Sci.)
443001, Samara, ul. Chapaevskaya, 227
P. Boriskin
LLC «TestGen»
Russian Federation
Russian Federation
PhD (Med. Sci.); research associate
432072, Ulyanovsk, 44th passage Engineering, house 9
A. Devyatkin
LLC «TestGen»
Russian Federation
Russian Federation
PhD (Med. Sci.); research associate
432072, Ulyanovsk, 44th passage Engineering, house 9
A. Toropovsky
LLC «TestGen»
Russian Federation
Russian Federation
PhD (Med. Sci.); general director LLC «TestGen»
432072, Ulyanovsk, 44th passage Engineering, house 9
V. Leonov
Medical University «Reaviz»
Russian Federation
Russian Federation
laboratory assistant
443001, Samara, ul. Chapaevskaya, 227
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Review
For citations:
Pavlova O., Gulenko O., Boriskin P., Devyatkin A., Toropovsky A., Leonov V. The relationship of the concentration distribution of diene conjugates in the blood serum and tissues of white outbred rats. Genetics and breeding of animals. 2020;(1):50-54. (In Russ.) https://doi.org/10.31043/2410-2733-2020-1-50-54
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