Study of the corrective effect of plant antihypoxants on lipid and phospholipid metabolism in rats during modeling of hemic hypoxia

Hypoxia, regardless of its origin, is in many cases the main factor in the formation of many pathological conditions and various diseases. The aim of the study is to study the disturbance of lipid and phospholipid metabolism in rats during modeling of hemic hypoxia.

Materials and methods. The studies were conducted on white outbred rats weighing 220-240 g. A model of hemic hypoxia was used. To determine lipoproteins, an electrophoretic method and standard techniques were used with standard sets of chemical reagents. The phospholipid spectrum was determined by thin-layer chromatography using silicone plates from Silufol.

Results. The results of the studies showed that in rats of group 1, the concentration of all phospholipid fractions during acute hemic hypoxia decreased by 5,4 % compared to the indices of intact animals, in rats of group 2 — by 6,5 %, in rats of group 3 — by 4,9 %, in rats of group 4 — by 3,1 %, and in rats of group 5 — by 5,6 % compared to the indices of intact rats. During hemic hypoxia, phospholipid metabolism disorders rapidly develop, characterized by a decrease in the proportion of total phospholipids, an increase in the concentration of LPH, a decrease in the level of the main phospholipid fractions PHH and an increase in PHEA, which indicates an increase in phospholipase activity in tissues.

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