Study of the biochemical status of calves in the early postnatal period in connection with dyspepsia

Purpose: to study changes in the most important metabolic parameters in case of dyspepsia in calves.

Materials and methods. Two groups of calves of 8 heads each, aged from 6 to 14 days, were formed. The first group included calves with signs of dyspepsia, who, in addition to diarrhea syndrome, had decreased appetite, weakness, and signs of abdominal pain. At the time of the study, the duration of the illness was 2-4 days. The second (control) group included clinically healthy animals of the same age. Blood was taken from the calves from the jugular vein in the morning before feeding. Blood serum was examined in a clinical biochemical laboratory using standard test systems to determine biochemical parameters.

Results. In calves with dyspepsia, a significant decrease in the concentration of triglycerides by 1,8 times, cholesterol by 1,57 times, total protein by 5,5 % and albumin by 12,3 % was revealed. They also revealed a significant increase in the activity of transamination enzymes — ALT (2,6 times) and AST (1,6 times), which may indicate both damage to hepatocytes and the induction of enzymes to accelerate transamination reactions in order to meet energy needs calf body. The studies did not reveal significant changes in the concentrations of urea, creatinine and bilirubin.

Conclusion. Studies have revealed metabolic changes that occur due to decreased absorption of nutrients in the intestines. Damage to the intestinal mucosa leads not only to a deterioration in the absorption of nutrients, but also to the penetration of proteins, primarily albumins, into the intestinal lumen and their removal from the body into the external environment. Redistribution of metabolic pathways to ensure homeostasis plays an adaptive role, but subsequently can have a negative role in the processes of growth and development of the calf’s body.

1. Animal physiology / L. Yu. Karpenko, A. I. Enukashvili, N. A. Panova [et al.]. – Ufa: Limited Liability Company "Aeterna", 2024. – 262 p.

2. Vasiliev R. M. Immunological parameters of blood serum of cows and calves with mycoplasmosis / R. M. Vasiliev // Issues of legal regulation in veterinary medicine. – 2012. – № 3. – P. 26–29.

3. The effect of the probiotic "Vetom 1.1" on the clinical status of calves with enterocolitis / V. A. Trushkin, S. P. Kovalev, A. A. Voinova [et al.] // Actual problems of veterinary medicine: Proc. International scientific and practical conference dedicated to the 90th anniversary of the birth of Professor V. A. Kirshin, Kazan, April 5–6, 2018. – Kazan: Federal Center for Toxicological, Radiation and Biological Safety, 2018. – P. 324–326.

4. Nikitina A. Study of metabolic processes in cows with hyperbilirubinemia in the postpartum period / A. Nikitina, S. Vasileva, R. Vasilev [et al.] // FASEB Journal. – 2022. – Vol. 36. — S1. – P. 3431. DOI 10.1096/fasebj.2022.36.S1.R3431.

5. Vasiliev R. M. Immuno-biochemical status of cows with genital mycoplasmosis / R. M. Vasiliev // Normative-legal regulation in veterinary medicine. — 2022. — № 1. — P. 35—37. DOI 10.52419/issn2782-6252.2022.1.35.

6. Experience of using the probiotic "Vetom 1.1" for enterocolitis in calves / V. A. Trushkin, S. P. Kovalev, I. V. Nikishina, A. A. Voinova // Actual problems of veterinary medicine: collection of scientific papers / Editorial board: Konopatov Yu. V., Belova L. M., Kryachko O. V., Kuzmin V. A., Shcherbakov G. G., Orekhov D. A., Ivanov V. S., Nechaev A. Yu., Klyauze V. M. Volume 148. — St. Petersburg: St. Petersburg State Academy of Veterinary Medicine, 2017. — P. 57—60.

7. Diseases of young cattle: Practical recommendations / D. N. Pudovkin, S. V. Shchepetkina, L. Yu. Karpenko, O. A. Rishko. - St. Petersburg: St. Petersburg State Academy of Veterinary Medicine, 2016. — 182 p.

8. Nikitina A. Comparative Assessment of the Content of Immunoglobulins in the Blood Serum of Calves Obtained From Healthy Cows and Cows with Genital Mycoplasmosis / A. Nikitina, R. Vasiliev, S. Kovalev, V. Trushkin // FASEB Journal. – 2022. – Vol. 36. — № S1. – P. 3467. DOI 10.1096/fasebj.2022.36.S1.R3467.

9. Vakhrusheva, T. I. Pathomorphological assessment and diagnostics of calf dyspepsia / T. I. Vakhrusheva // Bulletin of KrasSAU. — 2020. —№ 10 (163). — P. 150—161. DOI 10.36718 / 1819-4036-2020-10-150-161.

10. Kovalev S. P. Influence of the probiotic "Avena" on the clinical condition of calves with enteritis / S. P. Kovalev, V. A. Trushkin // Scientific notes of the Kazan State Academy of Veterinary Medicine named after N. E. Bauman. — 2014. — Vol. 218 — № 2. — P. 148—152.

11. Prevention and treatment of dyspepsia in newborn calves: a textbook for universities / A. Ya. Batrakov, K. V. Plemyashov, V. N. Videnin, A. V. Yashin, A. Ya. Batrakov, K. V. Plemyashov, V. N. Videnin, A. V. Yashin. — St. Petersburg: Limited Liability Company "Quadro", 2021. — 56 p.

12. Vasiliev R. M. Phagocytosis indicators in calves obtained from healthy cows and cows with genital mycoplasmosis / R. M. Vasiliev // Proceedings of the national scientific conference of the faculty, researchers and postgraduate students of St. Petersburg State University of Medicine, St. Petersburg, January 24-28, 2022. – Saint Petersburg: Saint Petersburg State University of Veterinary Medicine, 2022. – P. 14–16.

13. Galieva Z. A. An effective method for treating diarrhea in young cattle / Z. A. Galieva, Z. Z. Ilyasova, I. R. Gazeev, S. R. Ziyangirowa // Bulletin of the Orenburg State Agrarian University. – 2018. – No. 1(69). – P. 131–134.

14. Yashin A. V. Features of the state of the microcirculatory bed and membrane digestion in newborn calves with dyspepsia / A. V. Yashin, A. V. Prusakov // International Bulletin of Veterinary Medicine. – 2021. – № 2. – P. 155–160. DOI 10.17238/issn2072-2419.2021.2.155.